Key facts
- The National Institutes of Health (NIH) has launched a new office called ORIVA to reduce animal testing.
- The initiative aims to promote alternative research methods like computational models and 3D human tissue models.
The National Institutes of Health (NIH) announced the launch of a new office, the Office of Research Innovation, Validation, and Application (ORIVA), aimed at reducing animal-based research testing and promoting alternative methods.

This initiative signals a significant shift in federal research policy towards more ethical and potentially more effective scientific methodologies, impacting the future of biomedical research and drug development.
The National Institutes of Health (NIH) has announced the establishment of a new office, the Office of Research Innovation, Validation, and Application (ORIVA), dedicated to reducing the use of animals in research and promoting alternative testing methods. This move aligns with broader goals within the Department of Health and Human Services (HHS) under Secretary Robert F. Kennedy Jr., who has expressed a commitment to phasing out animal experimentation.
NIH Director Jay Bhattacharya highlighted the advancements in computational models and 3D human tissue models as key to a more effective research enterprise. The FDA and EPA have also recently introduced initiatives aimed at decreasing reliance on animal studies. The ORIVA office will support these alternative methods, including complex computational models and 3D human tissue models, to advance biomedical research.
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