Key facts
- Eclipsebio launched eSENSE Break, an addition to its eCOMPASS platform.
- eSENSE Break maps RNA fragmentation sites at single-nucleotide resolution.
- The tool analyzes linear mRNA, self-amplifying RNA, and circular RNA therapeutics.
- It provides positional data by pinpointing fragmentation hotspots in linear mRNA.
Understanding RNA fragmentation is crucial for developing effective RNA therapeutics. Fragmentation can impact the stability, efficacy, and immunogenicity of these therapies. Tools that can precisely map these fragmentation sites are therefore valuable for researchers and developers in the field.