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Over-40s with obesity have normal-BMI cholesterol and blood pressure levels, study finds

Created at 2 Jul · 7:20 AM1 source↑ Market-relevant
IN SHORT

A study published in The Lancet found that many adults over 40 with obesity have cholesterol and blood pressure levels comparable to those with a healthy weight, largely due to the widespread use of statins and blood pressure medications.

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Key Numbers

1 millionadults studied
1990-2024study period
40age threshold for convergence
20-79age range of participants

Who's Involved

Majid Ezzati
Professor at Imperial College London's School of Public Health
Edward Gregg
Professor at Imperial College London
Yse d’Ailhaud de Brisis
Author from Imperial College London
Bryan Williams
Chief Scientific and Medical Officer at the British Heart Foundation
The Lancet
Journal where the study was published
British Heart Foundation
Commented on the study's findings

↳ Why This Matters

The study's findings are significant for understanding the cardiovascular health of individuals likely to be prescribed weight-loss medications and highlight the effectiveness of modern treatments in mitigating obesity-related risks for older adults, while also underscoring the persistent risks for younger populations.

Key facts

  • A study found that many adults over 40 with obesity have cholesterol and blood pressure levels similar to those with a normal BMI.
  • This convergence is largely attributed to the increased use of statins and blood pressure medications.
  • The study analyzed data from almost 1 million adults across seven countries between 1990 and 2024.
  • Unhealthy cholesterol and blood pressure levels declined over time, with larger decreases observed in individuals with obesity.
  • For adults under 40, obesity was still associated with higher levels of unhealthy cholesterol and blood pressure.
  • Experts emphasized that obesity still carries risks for other health conditions beyond cardiovascular factors.

A study published in The Lancet indicates that many adults over the age of 40 who are obese have cholesterol and blood pressure levels that are indistinguishable from, or even better than, those with a normal body mass index (BMI). Researchers analyzed data from nearly 1 million adults across England, Japan, South Korea, Taiwan, Thailand, Finland, and the USA, collected between 1990 and 2024.

The findings suggest that advancements in medical treatments, particularly the widespread use of statins to lower cholesterol and antihypertensive drugs to reduce blood pressure, have significantly narrowed or eliminated the cardiovascular risk factor gap between obese and normal-weight individuals in this age group. The study observed that unhealthy cholesterol levels and blood pressure declined over time, with these declines being more pronounced among individuals with obesity, leading to a convergence of these cardiometabolic traits.

However, the study also highlighted that for adults under the age of 40, obesity remains associated with higher levels of unhealthy cholesterol and elevated blood pressure. Experts emphasized that while these findings represent a public health success in managing cardiovascular risk for older adults, obesity still contributes to increased risks for other health problems, such as diabetes, kidney disease, and certain cancers. They stressed the importance of continued lifestyle interventions, screening, and appropriate medication for younger adults to prevent long-term complications.

Frequently asked questions

The study found that many adults over 40 with obesity have cholesterol and blood pressure levels comparable to those with a normal BMI, largely due to medication use.

The widespread use of cholesterol-lowering drugs like statins and blood pressure medications has helped reduce these risk factors, especially in older adults with obesity.

No, the study emphasizes that obesity still increases the risk of other health problems such as diabetes, kidney disease, and some cancers, particularly in adults under 40.

For adults under 40, obesity is still linked to higher cardiovascular risk factors, suggesting a need for early lifestyle interventions, screening, and appropriate medication.

What Happens Next

01Consideration of early lifestyle interventions, screening, and medication for adults under 40 with obesity.
02Healthcare systems to understand how blood pressure and cholesterol treatments benefit the population alongside weight-loss medications.

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How It Developed

A study examined data on nearly 1 million adults from 1990-2024.
Researchers found unhealthy cholesterol and blood pressure declined over time, especially in those over 40.
Declines were larger among people with obesity, leading to convergence of risk factors.
In some countries, older adults with obesity were indistinguishable from or better off than normal-BMI individuals regarding non-HDL cholesterol and systolic blood pressure.
The study noted that obesity still increases risk for other health outcomes.
For adults under 40, obesity was still linked to higher bad cholesterol and blood pressure.
Experts highlighted the success of modern treatments for blood pressure and cholesterol.

Sources

T1
Over-40s with obesity have normal-BMI cholesterol and blood pressure levels, study findsThe Guardian

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